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KMID : 0382619820020010217
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Hanyang Journal of Medicine
1982 Volume.2 No. 1 p.217 ~ p.228
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Studies on Activities of Nucleases in Urologic Tumor. Tissues
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吳達逢/Oh, Dal Bong
金東翰/高在炅/Kim, Dong Han/Koh, Jai Kyung
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Abstract
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In order to understand the metabolic significance of changes in the activities ofenzymes involved in degradation of nucleic acids in urologic tumor tissues, the activities of acid DNase, acid RNase and 5´-nucleotidase were determined in tissues of benign prostatic hyperplasia, prostate cancer, bladder cancer and .renal cell cancer. Also determined were, concentrations of protein, DNA and RNA in these tumor tissues. The activities of the serum enzymes were measured to see whether there were any changes in serum in patients with these tumors.
(1) Activities of acid DNase and RNase were greatly increased in tissues of bladder cancer suggesting that these two enzymes may play important roles in carcino-genesis of urinary bladder cells, facilitating the reactions involved in DNA. integration and the biosynthesis of cancer specific RNA.
(2) In prostate cancer tissues, activities of acid DNase, acid RNase and 5´-nucleotid-ase were all decreased significantly. The decreases in the enzyme activities. may be due, in part, to tissue destruction reported to take place in certain types, of cancer and this assumption is supported by the observation that concentrations" of protein, DNA and RNA were also decreased significantly in prostate cancer, tissues.
(3) While the activity´ of acid RNase was significantly increased in renal cell cancertissues, activities of acid DNase and 5´-nucleotidase were not changed.
(4) In bladder cancer tissues, concentrations of DNA and RNA were significantlyincreased, but the concentration of protein was unchanged. On the other hand; concentrations of protein and RNA were significantly . increased in renal cell_ cancer tissues, and the DNA content was not changed.
(5) While activities of serum acid DNase and 5´-nucleotidase were not changed in. patients with urologic tumors, the. activity of serum acid RNase was significantlyincreased in patients with prostate cancer. These results suggest that the measurement of serum acid RNase may be an useful tool for diagnosis of prostate cancer.
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KEYWORD
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